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Author

Lu Liu

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Oct 2026

Immunoregulatory artificial lymph nodes restore antigen-specific tolerance in advanced multiple sclerosis.

Tolerogenic dendritic cell (tolDC) vaccines are a promising antigen-specific therapy for multiple sclerosis (MS), yet their efficacy is limited by poor homing to secondary lymphoid organs and rapid loss of the tolerogenic phenotype in native inflamed lymph nodes. Here, we developed a 3D-printed tolerogenic artificial l...

Jing-Sen Ji, Xin-Huan Wang, Lu Liu et al. · 0 citations
Review Open access Jul 2026

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

Genomic manipulation has advanced from stochastic nuclease‐mediated disruption toward programmable, deterministic precision. Early clustered regularly interspaced short palindromic repeats (CRISPR) strategies enabled targeted mutagenesis through double‐strand breaks; however, their therapeutic application is limited by...

Ke-Rui Huang, Jianhong Tian, Wen-Yan Zhao et al. · 3 citations

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