Focused Ultrasound-Enhanced Delivery of ED5, a CK1α-Targeting Oleanolic Acid Analogue, Suppresses Glioma Growth via MAPK-ROS-ERS Pathway Modulation.
AIM The objective of this study was to assess the anticancer efficacy of ED5, a new oleanolic acid (OA) analogue and selective casein kinase 1α (CK1α) inhibitor, and to ascertain if focused ultrasound (FUS) can improve its delivery and therapeutic effect against glioma. The authors carried out in vitro, in vivo, and me...