Lu-Ping Yang

AKAP1 orchestrates mitochondrial dynamics and metabolic reprogramming to promote hypoxia tolerance in yak cardiac fibroblasts.

High-altitude hypoxia poses a sustained energetic and oxidative challenge to the heart, often leading to mitochondrial dysfunction and metabolic inflexibility in nonadapted mammals. Yaks (Bos grunniens) exhibit remarkable cardiac tolerance to chronic hypoxia; however, the underlying intracellular mechanisms remain poor...