Author

Lu Tan

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Open access Aug 2026

Transmetallic biomimetic Hydrogel implants restore osteogenesis-angiogenesis coupling via Fe/Co ionic microenvironment remodeling for enhancing osteoporotic fracture healing

The regeneration of osteoporotic bone fractures remains a significant clinical challenge, primarily due to the iron overload-induced functional impairment in osteoporosis-angiogenesis coupling. Here, we developed a transmetallic biomimetic hydrogel implant (TBH) to address this issue. The TBH was fabricated by crosslin...

Hao Wei, Xin-Qiang Hu, Maohua Chen et al. · Bioactive Materials · 0 citations

Open access Sep 2026

Acid‐Responsive Nanobot‐Integrated Core‐Shell Microneedles Reprogram the Degenerative Annulus Fibrosus Microenvironment Through Epigenetic Suppression of Ferroptosis

ABSTRACT Annulus fibrosus (AF) rupture is a key structural event in intervertebral disc degeneration, but effective repair is hindered by the acidic, hypoxic and oxidative microenvironment of the avascular disc. Single‐cell transcriptomic reanalysis and clinical AF specimens identified ferroptosis‐associated redox imba...

Lu Tan, Yan Zheng, Yue Lan et al. · Advancement of science · 0 citations