Review
Open access
Sep 2026
Lactylation in liver fibrosis: from molecular mechanisms to targeted therapeutic strategies
Metabolic reprogramming and epigenetic remodeling of hepatic stellate cells (HSCs) represent central driving events in liver fibrosis. Lactylation, a lactate-mediated post-translational modification (PTM), is proposed to converge on histone H3 lysine 18 lactylation (H3K18La) through the HK2-KAT8 positive feedback loop,...
Zhi-Wei Dong, Fei-Bo Xu, Mei Ye et al.
· Frontiers in Pharmacology · 0 citations