Open access
Sep 2026
Targeting SHMT2 reverses lactate-driven CAF-mediated T-cell exclusion and sensitizes HNSCC to anti-PD-1 immunotherapy
Resistance to PD-1/PD-L1 blockade in head and neck squamous cell carcinoma (HNSCC) is frequently attributed to an “immune-excluded” tumor microenvironment (TME); however, the tumor-intrinsic metabolic drivers orchestrating this spatial remodeling remain poorly defined. Here, we identify serine hydroxymethyltransfer...
He-Lei Yan, Lu Wang, Zhen Li et al.
· Cell Death & Disease · 0 citations