Lu Yang

A Pathway-Economical Synthesis Enabling Systematic Evaluation: Enantiodivergent Access to Aspidosperma Alkaloids Unlocks Divergent Antitumor Mechanisms

The difficulty in efficiently accessing to both enantiomers has long hampered the systematic evaluation of how chirality governs the bioactivity of natural products. We report a pathway-economical synthesis that addresses this challenge, unlocking enantiodivergent access to ten Aspidosperma alkaloids. The highlight o...