Catalytic Enantioselective Remote Transannular Desymmetrization of Calix[4]Arenes to Inherently Chiral Double-Macrocycles.
There has been a recent surge in research aimed at synthesizing inherently chiral macrocycles that lack point, axial, planar, or helical chirality. To overcome the structural limitations of existing inherently chiral macrocyclic systems, which often suffer from facile racemization due to conformational flexibility, we...