Skip to content
Log in
Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Luc Brunsveld

h-index 9 View on Semantic Scholar

We have 5 of 37 papers

We haven’t gathered this author’s papers yet. Follow them and we’ll fetch their work.

Not the right person? Other researchers publish under this name.

Open access Aug 2026

A Molecular Mechanistic Deep Dive into 14-3-3 Molecular Glue Cooperativity.

Molecular glues (MGs) stabilize protein-protein interactions (PPIs) through interactions at composite binding interfaces, thereby promoting cooperative ternary complex formation. For hub proteins that engage in multiple PPIs with widely varying intrinsic affinities, the interplay between binary PPI affinity and MG coop...

Marloes A. M. Pennings, Edmee M. F. Vandenboorn-Bönner, Lisa Nooren et al. · 0 citations
Open access Aug 2026

14-3-3/Tau molecular glues modulate in vitro tau condensation

The intrinsically disordered protein Tau is highly phosphorylated under pathological conditions, which, among others, results in Tau liquid–liquid phase separation (LLPS), followed by aggregation. The hub protein 14-3-3 regulates Tau protein solubility and prevents LLPS by binding with phosphorylated Tau residues pS214...

Maxime C. M. van den Oetelaar, Leandre M. Ravatt, Francisco Maqueda Zelaya et al. · 0 citations
Open access Sep 2026

C-RAF Sequence-Encoded Cooperativity Hotspots for 14-3-3/C-RAF Molecular Glues

14-3-3 Proteins are hub proteins with an extensive interactome of phosphorylated client proteins, making them attractive targets for molecular glues (MGs) that stabilize specific 14-3-3/client protein complexes. However, selectively stabilizing individual 14-3-3 protein−protein interactions (PPIs) remains a key chall...

Marloes A. M. Pennings, G. Lauffer, Markella Konstantinidou et al. · 0 citations
Open access Aug 2026

Molecular Glue and Phosphorylation-Dependent 14-3-3 Recruitment to p53 with an Engineered Interaction Cassette.

These results establish a modular, MG- and phosphorylation-dependent platform for engaging 14-3-3 in a p53 context and for evaluating how chemical stabilization translates from biochemical interaction control to cellular pathway-level readouts.

Diana C. Muñoz-Lasso, Yan Ni, G. Weber et al. · 0 citations
Open access Jul 2026

Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC

A molecular glue-stabilizer and PROTAC strategies are combined to enable ubiquitination of the 14-3-3/estrogen receptor α complex, revealing cooperative linker-dependent activity and a structural basis for targeted E3 ligase recruitment.

Carlo J. A. Verhoef, Charlotte Crowe, M. Nakasone et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.