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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

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Lucia Sommerova

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Open access Sep 2026

ATM safeguards DNA replication by restraining pathological repriming at endogenous base lesions.

Poly(ADP-ribose) polymerase inhibitors (PARPi) exploit homologous recombination (HR) deficiency in BRCA1/2-mutant cancers to induce synthetic lethality. PARPi also kill ataxia telangiectasia-mutated (ATM)-deficient cells, but the underlying mechanism has remained unclear. Here, we define the mechanism of PARPi cytotoxi...

Lucia Sommerova, Ashleigh King, J. Chapman · 0 citations

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