Author

Luigi Celauro

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Open access Sep 2026

Prion Protein Deficiency Results in Synaptic, Neural Network and Behavioral Alterations

The cellular form of the prion protein (PrPC) is known for its involvement in the pathogenesis of prion diseases. Recent research implicates the physiological isoform of PrP in neuronal development, excitability, and synaptic plasticity, as well as in other biological processes. However, its precise function in the dev...

Anna Burato, Alessio Di Clemente, Camilla Lodetti et al. · bioRxiv · 1 citation

Open access Oct 2026

MicroRNA 517a-3p suppresses α-synuclein fibril accumulation in human glioblastoma cells

Synucleinopathies are a group of neurodegenerative disorders characterized by the misfolding, aggregation, and accumulation of α-synuclein (α-syn) into oligomeric assemblies and amyloid inclusions. Alongside neurons, glial cells can internalize pathological α-syn and play a major role in its degradation. Despite...

Lea Šustić, Elena de Cecco, Sandesh Neupane et al. · Cell Communication and Signa... · 0 citations