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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Luis Aragon

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2 papers indexed here

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Open access Sep 2026

Negative supercoiling facilitates human TOP3α-mediated decatenation of DNA braids via catenation junction melting

DNA catenation between sister chromatids arises during replication and must be efficiently resolved to ensure faithful chromosome segregation. The removal of DNA catenation is generally attributed to the type II topoisomerase TOP2α, which catalyses double-stranded DNA passage reactions and can therefore directly remove...

Sanjana Saravanan, Anno I. Koetje, Graeme A. King et al. · 0 citations
Open access Oct 2026

Human FACT complex coordinates cohesin and transcription on chromatin

The spatial organisation of eukaryotic genomes is critical for coordinating DNA-dependent processes such as transcription and replication. Cohesin contributes to this organisation by extruding chromatin loops; however, how cohesin achieves processive translocation along nucleosome-dense chromatin in vivo remains poorly...

Jonay García-Luis, A. Canela, V. Malysheva et al. · 0 citations

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