Effectiveness of first-line ET plus CDK4/6i in patients with HR+/HER2− aBC worsens progressively with decreasing ERα expression, and PgR expression adds further prognostic discrimination, with low ERα and PgR expression identifying a subgroup of patients with particularly poor outcomes.
F. Ligorio, L. Provenzano, R. Caputo et al.· EClinicalMedicine· 0 citations
Mitophagy is a selective form of autophagy, essential to maintain cellular homeostasis by removing damaged and dysfunctional mitochondria. Several lines of evidence suggest that defective mitophagy is associated with various diseases, including breast cancer. Disruption of mitochondrial quality control contributes to t...
Silvia Zunico, Giorgia Pisano, C. Della Bella et al.· Cells· 0 citations
BackgroundIn advanced breast cancer, treatment pathways are becoming increasingly prolonged and complex across different biological subtypes. New systemic and targeted therapies require long-term monitoring and careful personalization according to patient-specific factors that demand increasingly individualized therape...
O. Tinelli, C. von Arx, R. Caputo et al.· Epidemiology Biostatistics a...· 0 citations
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