Author

Lujia Feng

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Aug 2026

Blocking the RhoA/ROCK/cofilin/F-actin Pathway via Y27632 Protects Against MERTK-deficient Retinal Degeneration and Visual Function Impairment.

It is shown that MERTK maintains RPE survival and phagocytosis via regulating the RhoA/ROCK/cofilin/F-actin axis and rescued the MERTK depletion-induced phagocytic dysfunction and apoptosis of HsRPE cells and rat RPE.

Lujia Feng, Ting Zhang, Yong Du et al. · Current Medicinal Chemistry · 0 citations

Open access Jun 2026

NAD+ modulates mitochondrial vulnerability in MERTK-associated models of retinitis pigmentosa

It is shown that the NAD+ precursor NMN protects against retinal degeneration by improving mitochondrial function in MERTK-associated models, offering potential therapeutic insights.

Lujia Feng, Yuwen Wen, Ting Zhang et al. · Nature Communications · 0 citations

Jul 2026

Targeting the SNAI1-LAMP3 axis to restore lysosomal function and alleviate autophagic flux impairment to delay retinal degeneration.

Findings indicate that the SNAI1-LAMP3 axis contributes to the regulation of the autophagy-lysosomal pathway in retinal degeneration, highlighting a potential therapeutic target for delaying disease progression.

Yuke Ji, Yanan Sun, Xiaosheng Huang et al. · Autophagy · 0 citations