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Author

Lukas Müller

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Open access Jul 2026

Reassessing Tcf21-iCre for Adult Cardiac Fibroblast Gene Deletion: Limited Recombination Efficiency Following Tamoxifen Injections

Highlights What are the main findings? Tcf21-iCre demonstrates minimal recombination efficiency in adult cardiac fibroblasts after tamoxifen injection, with mono-allelic events indicating low Cre activity. Neither pro-fibrotic stress nor additional tamoxifen dosing improves recombination efficiency. What are the implic...

A. Schober, Lukas Müller, R. Wardman et al. · 0 citations
Open access Aug 2026

A p32 family RNA editing factor acts in mitochondrial ribosome biogenesis

Biogenesis of mitochondrial ribosomes (mitoribosomes) in the unicellular parasite Trypanosoma brucei requires an exceptionally large toolkit of assembly factors, identified in stable precursors of large and small mitoribosomal subunits (mtLSU and mtSSU) by cryoEM. Here, using genetic modifications and proteomic charact...

Prashant Chauhan, Ingrid Sveráková-Škodová, J. T. Wong et al. · 0 citations

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