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Lun-Zhi Yuan

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Open access Sep 2026

A late-stage multi-dimensional intervention rescues lethal viral pneumonia in an aged hamster model

Severe pneumonia caused by respiratory virus infection is one of the main threats to the lifespan of the aged population and physiological aging fundamentally drives poor disease outcomes in respiratory viral infections, necessitating investigation of the underlying mechanisms and the development of effective counterme...

Ming Zhou, Xuan Liu, Jinxin Miao et al. · 0 citations
Open access Sep 2026

An Engineered Spike Immunogen Drives Broad Protection of a Bivalent Recombinant Protein COVID-19 Vaccine in Animal Models

The continued evolution of SARS-CoV-2 has reduced the protective effectiveness of first-generation vaccines and underscores the need for broadly reactive next-generation vaccine candidates. Here, we evaluated STFKB, an alum-adjuvanted bivalent recombinant protein vaccine composed of the monomeric Spike (STFKprototype)...

Zi-Kang Wang, Jia-Hua Gao, Ru Bai et al. · 0 citations
Aug 2026

Lineage-specific pulmonary transcriptome landscape of coronavirus infection unveils universal immunotherapy for viral pneumonia.

It is demonstrated that a rational combination of pharmacological targeting of innate and adaptive immune responses is sufficient to reduce mortality and severe illness caused by beta, delta and EG.1 variants in SARS-CoV-2 infection.

Ming Zhou, Xuan Liu, Haiqing Xiao et al. · 0 citations

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