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Aug 2026
ProtoPSR: Prototype-guided Pairwise Similarity Regularization for Robust Spatial Multi-Omics Integration
ProtoPSR is proposed, an unsupervised framework for robust spatial multi-omics domain discovery that stabilizes both local clustering structure and global pairwise relations and demonstrates strong robustness under modality-specific feature corruption.
Yu Zhang, Meng-Zhu Wang, Luoxi Jing et al.
· Proceedings of the 32nd ACM... · 0 citations