Abstract INTRODUCTION We compared the association between mild behavioral impairment (MBI) and first‐ versus second‐generation tau‐positron emission tomography (PET) tracers in preclinical and prodromal Alzheimer's disease (AD). METHODS We assessed 110 individuals with head‐to‐head [18F]MK6240 and [18F]Flortaucipir tau...
I. Bizzi, Arthur C. Macedo, Lydia Trudel et al.· Alzheimer's & Dementia· 0 citations
It is shown that elevated plasma GFAP significantly modulates the association between p-tau217 and both cross-sectional cognitive severity and longitudinal clinical decline, and support that astrocyte reactivity is associated with greater cognitive impairment and faster clinical decline among individuals with elevated...
B. Bellaver, G. Povala, P. C. L. Ferreira et al.· Molecular Neurodegeneration· 0 citations
Conventional phosphorylated tau (p‐tau)217 reliably identifies amyloid positron emission tomography (PET) positivity, but its ability to capture the full Aβ continuum is limited.
Lydia Trudel, J. Therriault, Arthur C. Macedo et al.· Alzheimer's & Dementia· 0 citations
Across regions and networks, SEOT performed similarly or better than tau load in predicting metabolic dysfunction and may improve diagnostic characterisation and prediction of cognitive impairment beyond [18F]FDG-PET.
Arthur C. Macedo, Lydia Trudel, S. A. Hosseini et al.· EBioMedicine· 1 citation
The results show that the MINT is adequately valid and effective to replace the BNT in neuropsychological assessment in the Quebec French population and performed better at discriminating dementia from cognitively unimpaired participants than at identifying MCI.
Felix-Etienne Colpron-Larin, É. Aumont, Samantha Schwartz et al.· Applied neuropsychology. Adu...· 0 citations
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