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Author

Lyle A. Simmons

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Open access Sep 2026

DNA polymerase I and DnaE mediate RNA-templated DNA synthesis over embedded ribonucleotides

Abstract It is established that during normal growth and under stress, ribonucleotides become nested in genomic DNA. Given the high frequency with which RNA is found in DNA, it is unknown which bacterial DNA polymerases are responsible for catalyzing RNA-dependent DNA synthesis. In this work, we establish bacterial DNA...

F. Lowder, Abigail H. Kendal, Lyle A. Simmons · 0 citations
Review Open access Jul 2026

Ribonucleotide errors, RNase HII, and ribonucleotide excision repair

Replicative DNA polymerases are responsible for the high-fidelity duplication of genomes in all organisms. The overall DNA replication process is highly accurate, with deoxyribonucleoside monophosphate (dNMP) errors occurring on the order of 1 in tens of millions of replicated bases. However, DNA polymerases are more p...

Julianna R. Cresti, Lyle A. Simmons · 0 citations

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