Quercetin-mediated selenium nanoparticles protect against hyperthyroidism-induced hepatic injury: Involvement of Nrf2/NF-κB signaling, mitochondrial apoptosis, and iron/heme imbalance.
PURPOSE Hyperthyroidism-associated liver injury represents an important extra-thyroidal complication of thyroid hormone excess, driven by increased metabolic demand and interconnected oxidative, inflammatory, and mitochondrial disturbances. However, the coordinated involvement of Nrf2/NF-κB signaling, apoptosis, and ir...