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Open access 2026

Prediction of pharmacokinetics and molecular docking of new 1,2,3,4-tetrahydropyrimidine derivatives linked to carbohydrazide by aromatic and heteroaromatic linkers

The potential of 1,2,3,4-tetrahydropyrimidine–carbohydrazide hybrids as promising scaffolds for the design of selective HDAC8 inhibitors is demonstrated and provides valuable insights for further structural optimization and synthesis.

Ameer Alwash, Sumia Tayeh, M. Ahmed et al. · 0 citations

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