Author

M. Al-Khreisat

3 papers indexed here

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Review Sep 2026

Pyroptosis in Triple-Negative Breast Cancer: From Inflammasome Signaling to Tumor Immune Remodeling and Translational Therapeutic Strategies.

Triple-negative breast cancer (TNBC) remains an aggressive breast cancer subtype marked by molecular heterogeneity, immune evasion, limited actionable targets, and variable responses to immune-based therapy. Pyroptosis, a gasdermin-mediated inflammatory form of regulated cell death, may link tumor-cell injury to remode...

Qamar Abuhassan, M. Al-Khreisat, R. Roopashree et al. · Progress in Biophysics and M... · 1 citation

Review Aug 2026

AEG-1/MTDH: A central regulator of tumor progression, metabolic adaptation, and therapeutic resistance in gliomas.

Astrocyte-elevated gene-1 (AEG-1), also known as metadherin (MTDH), is a pleiotropic oncogene critically involved in the onset and development of glioblastoma (GBM), other malignant gliomas, and neuroblastoma. Its expression is upregulated under hypoxic conditions and during glucose deprivation, enabling tumor cells to...

S. Mohammad, A. Vasudevan, M. Al-Khreisat et al. · Tissue & Cell · 0 citations

Review Open access Aug 2026

The CREM–IL-15 axis: decoding the persistence–exhaustion paradox in NK cell immunotherapy

Natural killer (NK) cells are critical components of the innate immune system, renowned for their ability to recognize and eliminate malignant and infected cells without prior sensitization. NK cell immunotherapy encompasses various approaches, including adoptive transfer of ex vivo expanded NK cells, cytokine stimulat...

Amr A. El-Sehrawy, M. Al-Khreisat, Jalpa R. Patel et al. · Cancer Immunology and Immuno... · 0 citations