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Author

M. Aladjem

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Oct 2026

Genome-wide CRISPR screen identifies PKMYT1 inhibition as a synthetic lethal vulnerability in IDH1-mutant glioma.

Mutations in isocitrate dehydrogenase (IDH) are frequently observed in several aggressive malignancies, including gliomas, chondrosarcomas, and acute myeloid leukemia. Mutant IDH enzymes exhibit neomorphic activity that produces the oncometabolite D-2-hydroxyglutarate (D-2-HG), leading to widespread DNA and histone hyp...

Feng-Chao Lang, Hai-Qing Fu, Karambir Kaur et al. · 0 citations
Open access Oct 2026

53BP1 condensates regulate DNA replication progression and completion.

DNA replication in mammalian cells proceeds in chromosomal domains during defined windows of S phase; however, the mechanisms coordinating replication with restoration of chromatin states remain incompletely understood. Here, we identify p53-binding protein 1 (53BP1) condensates as regulators of heterochromatin replica...

Fang-Fang Wang, Xin-Ran Geng, Jun-Qiu Zhang et al. · 0 citations
Open access Aug 2026

Therapeutic NAMPT inhibition reveals a targetable metabolic vulnerability in neuroblastoma

NB is identified as a highly NAMPT inhibitor-sensitive pediatric solid tumor and NAMPT-dependent NAD + biosynthesis as a targetable metabolic vulnerability in this disease is established.

Sophia Varriano, Amy Yu, Abantika Chakraborty et al. · 0 citations

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