Lentivirus (LV)-based manipulation of immune cells is a commonly used approach in cell therapies. However, the most frequently used Vesicular Stomatitis Virus Glycoprotein (VSV-G) pseudotyping approach is inefficient to support LV gene delivery of mouse immune cells due to the lack of an optimal entry receptor. Here, w...
Jian Li, Beatriz Goncalves, Gabrielle Melamed et al.· Frontiers in Immunology· 0 citations
These findings provide proof-of-concept that epitope-focused nanoparticle immunogens can target partially occluded, immunoquiescent bnAb epitopes, laying the groundwork for pan-betacoronavirus vaccines that provide broad protection and strengthen pandemic preparedness.
Panpan Zhou, Ziqi Feng, Wan-ting He et al.· bioRxiv· 0 citations
This approach provides a framework for targeting ADO-mediated immune suppression of CD8+T cells in HIV and other disease landscapes, including cancer, and establishes targeted ADA-1 delivery as a novel strategy to enhance CD8+ T-cell function.
Arden O. Edgerton, Dillon O'Neill, David Joyner et al.· Journal of Immunology· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.