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M. Alameh

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Open access Oct 2026

An inducible human LDLR transgenic mouse model for enhanced lentiviral gene delivery to murine immune cells

Lentivirus (LV)-based manipulation of immune cells is a commonly used approach in cell therapies. However, the most frequently used Vesicular Stomatitis Virus Glycoprotein (VSV-G) pseudotyping approach is inefficient to support LV gene delivery of mouse immune cells due to the lack of an optimal entry receptor. Here, w...

Jian Li, Beatriz Goncalves, Gabrielle Melamed et al. · 0 citations
Open access Aug 2026

Protective pan-betacoronavirus neutralizing antibodies by vaccination

These findings provide proof-of-concept that epitope-focused nanoparticle immunogens can target partially occluded, immunoquiescent bnAb epitopes, laying the groundwork for pan-betacoronavirus vaccines that provide broad protection and strengthen pandemic preparedness.

Panpan Zhou, Ziqi Feng, Wan-ting He et al. · 0 citations
Open access Jul 2026

Targeting the Adenosine—Adenosine Deaminase-1 Axis to Restore HIV-Specific CD8+ T Cell Function 2309228

This approach provides a framework for targeting ADO-mediated immune suppression of CD8+T cells in HIV and other disease landscapes, including cancer, and establishes targeted ADA-1 delivery as a novel strategy to enhance CD8+ T-cell function.

Arden O. Edgerton, Dillon O'Neill, David Joyner et al. · 0 citations

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