Open access
Aug 2026
Cascading damage to Candida albicans cells through thioredoxin reductase loss
It is proposed that metabolic pathway competition for this shared intermediate between NADPH production and cell wall glucan biosynthesis underlies the cell wall weakness of TRR1-depleted cells, and decreased activity of a key UDP-glucose biosynthetic enzyme supports this mechanism.
Wan-Jun Qi, Udita Roy, Chun-Hui Cai et al.
· Proceedings of the National... · 0 citations