M. Arafat

Multi-modal single-cell and genetic integration defines cytotoxic T-cell regulatory states, HSPC suppression and inherited susceptibility in aplastic anaemia

Acquired aplastic anaemia is caused by immune-mediated loss of haematopoietic stem and progenitor cells (HSPCs), but the regulatory states that sustain cytotoxic immunity and their relationship to inherited susceptibility remain incompletely understood. We integrated two single-cell RNA-sequencing cohorts spanning heal...