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Open access Aug 2026

Design, Synthesis, In Vitro Biological Evaluation, and In Silico Analyses of Novel Pyrano[3,4‑b]indole-Containing Compounds as Promising Multitarget Candidates for Alzheimer’s Disease and Cancer Therapy

Findings indicate that the synthesized pyrano[3,4-b]indole derivatives have inhibitory potential for AD and cancer, and the synthesized compounds showed promising results for the treatment of AD and cancer.

Ferah Comert Onder, Alper Onder, Kadircan Ural et al. · 0 citations
Open access Jul 2026

New 3H-1,2-Dithiole-3-thione derivatives: Design and synthesis, H2S-release profile, in vitro anticancer activity, and in silico multi-target assessment.

The findings identify particularly compound DTT-S8, as a promising in vitro anticancer candidate, while the computational results suggest a putative involvement of inflammation-related targets, particularly the COX-2/5-LOX axis, which requires direct biochemical and cellular validation.

Semra Altunsoy, Y. Yilmaz, T. Güngör et al. · 0 citations

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