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Author

M. Berretta

2 papers indexed here

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Review Open access Sep 2026

Mechanisms of resistance to PARP inhibitors in advanced epithelial ovarian cancer: biological determinants and therapeutic implications

PARP inhibitors have become an integral component of treatment strategies for advanced epithelial ovarian cancer, particularly in BRCA1/2 -mutated and homologous recombination-deficient (HRD) tumors. Despite clinically meaningful improvements in progression-free survival, a substantial proportion of patients develo...

D. Incognito, G. Ciappina, G. Ettore et al. · 0 citations
Review Open access Aug 2026

PIK3CA in Cancer: Structure, Biology, Alterations, and Actionability

Simple Summary PIK3CA is one of the most frequently altered cancer-related genes and has become an important focus of precision oncology. However, the biological and clinical implications of PIK3CA alterations vary considerably across tumor types, and translating this knowledge into effective treatments remains challen...

A. Ottaiano, Carmine Picone, M. Santorsola et al. · 0 citations

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