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It is concluded that TCF4 has dual activator-repressor activity in colon cancer, suggestive of competition centered on TCF4 transcriptional output despite the β-catenin saturated colon cancer nucleus.
The fruit fly Drosophila melanogaster is widely used to study conserved developmental and cellular signaling pathways in vivo. Many signaling pathways, including Wnt signaling, depend on tightly regulated secretion, endocytosis, and intracellular trafficking events. However, visualizing the dynamics of membrane-associa...
Functional assays demonstrated that WNT activation enhances tumor progression in immunocompetent settings, indicating immune evasion as a key driver of malignant progression.
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