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Author

M. Carrigan

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Open access Oct 2026

The modulatory role of early-life experiences and sex on cognitive resilience in APP/PS1 mice over time

BACKGROUND Cognitive resilience to Alzheimer’s disease (AD) can be modelled in amyloid-expressing rodents through early handling (EH). This study investigated how EH and sex affect cognition and pathology over time. METHODS We assessed cognition (open field, object recognition test, Barnes maze) in 6- and 12-month-old...

M. Carrigan, Jeniffer Sanguino-Gómez, Melis Bayer-Var et al. · 0 citations
Open access Jul 2026

Prognostic Value of Blood-Based P-Tau217 Levels for Progression to Cognitive Impairment.

Higher plasma p-tau217 levels were consistently associated with increased risk of clinical progression and accelerated cognitive decline, and support the potential of p-tau217 for prognostic model development, with direct implications for future trial design.

R. Buckley, D. Townsend, C. Birkenbihl et al. · 3 citations

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