Controlled Extension of the Tumor Promotion Period Enhances Progression of GSTP-Positive Hepatocellular Lesions in a Rat Model of Hepatocarcinogenesis.
Histochemical approaches are critical for detecting early, clinically silent stages of hepatocarcinogenesis; however, the widely used diethylnitrosamine/2-acetylaminofluorene initiation-promotion (IP) model is time-constrained, limiting evaluation of lesion progression beyond the preneoplastic stage. This study establi...