M. Çelebier

Metabolic impact of bisphenol A on retinal pigment epithelium: disturbed energy pathways and antioxidant response in ARPE-19 cells.

Bisphenol A (BPA) is a widely utilized endocrine-disrupting chemical that has been associated with metabolic dysregulation in various tissues. Nevertheless, its impact on ocular metabolism remains insufficiently understood. This study aims to investigate the metabolic effects of BPA exposure in ARPE-19 retinal pigment...

Untargeted LC-MS Metabolomics Reveals Source-Dependent Metabolic Remodeling of Caco-2 Cells Exposed to Bovine Hydatid Cyst Fluid.

Hydatid cyst fluid (HCF) is a biochemically complex parasite-derived mixture whose effects on host and cancer cells are highly context dependent. The aim of this study was to determine whether short-term exposure to bovine liver- or lung-derived HCF alters Caco-2 XTT-based viability/metabolic activity and to characteri...

Activated platelet rich plasma modulates the proliferation, apoptosis and matrix synthesis driven by growth factors in osteoarthritic chondrocytes: an in vitro study

Introduction Activated platelet‐rich plasma (aPRP) reduces inflammation and promotes regeneration in osteoarthritic knee joints. It may exert therapeutic effects on osteoarthritic chondrocytes (OACs) compared with healthy chondrocytes (HCs) by promoting cell proliferation, reducing autophagy‐related vesicles and inhibi...

Metabolomic Fingerprints of L-PRP and P-PRP: Formulation differences and Storage-induced Shifts.

Development, Validation and Application of an RP-HPLC Method for the Determination of Reproxalap in Cyclodextrin Inclusion Complexes and an In Situ Ocular Hydrogel

Background/Objectives: The aim of this study was to develop and validate a simple, accurate, reproducible, and sensitive reverse-phase high-performance liquid chromatography method for the quantification of reproxalap (RP) in cyclodextrin (CD) inclusion complexes and poloxamer 407 hydrogel formulations. Methods: Chroma...

Plasma Metabolic Features Associated with Developmental Regression in Autism Spectrum Disorder: A Pilot Untargeted Metabolomics Study

Several plasma metabolic features showing abundance differences among children with REG+, REG−, and typically developing controls are identified and require confirmation using authenticated standards, targeted quantitative methods, and independently recruited cohorts before any diagnostic, predictive, or therapeutic re...