Author

M. Choteau-Bodor

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Open access Oct 2026

The ARumenamide AR-788 suppresses the transient outward current in human iPSC-derived right-ventricular Brugada cardioids

Brugada syndrome (BrS) is an inherited arrhythmia disorder with limited drug therapy, quinidine being the principal agent. Loss-of-function variants in SCN5A reduce the cardiac sodium current (INa), but the arrhythmogenic imbalance also depends on the transient outward potassium current (Ito). Here we generated human i...

Y. Guéret, A. Girardeau, S. Godin et al. · medRxiv · 0 citations

Open access Sep 2026

Selective activation of tetrodotoxin-sensitive sodium channels by AaH-II drives arrhythmogenic late Na+ current in the heart

Abstract Increased late sodium current (INaL) is a central mechanism underlying both inherited and acquired cardiac arrhythmias. Although Nav1.5 is the dominant cardiac sodium channel, multiple tetrodotoxin-sensitive (TTX-S) Nav isoforms are also expressed in cardiomyocytes, particularly within transverse tubules, wher...

Hugo Millet, M. Choteau-Bodor, T. Stervinou et al. · Europace · 0 citations