Author

M. Christodoulides

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Review Open access Oct 2026

Pathogenicity and virulence of NEISSERIA GONORRHOEAE.

Neisseria gonorrhoeae causes the sexually transmitted infection gonorrhea and is an obligate human pathogen, colonizing mucosal epithelia of the male urethra and the female endo/ectocervix, resulting in urethritis and cervicitis. These manifestations represent uncomplicated gonorrhea and highlight the gonococcus as a p...

M. Girgis, M. Christodoulides · Virulence · 0 citations

Review Open access Sep 2026

Artificial Intelligence-Integrated Proteome-Wide Target Prioritization for Drug Discovery against Multidrug-Resistant Neisseria gonorrhoeae

Neisseria gonorrhoeae causes ∼82.4 million infections annually and is rapidly approaching an untreatable status. The pathogen has developed resistance to every antibiotic class introduced since the sulfonamide era. Ceftriaxone, the last WHO- and CDC-recommended empirical therapy, is now compromised by high-level resi...

Ravi Kant, S. Mazumdar, Ananya Mahajan et al. · ACS Infectious Diseases · 0 citations

Open access Aug 2026

The Activity of Antimicrobial Peptides (AMPs) Identified Via an Integrated in Silico and Pilot in Vitro Screening Approach Towards ESKAPE Pathogens.

A stability-centric computational discovery pipeline to identify and characterize novel antimicrobial peptides with potent and selective bactericidal activity against ESKAPE pathogens and to validate the lead candidates through experimental in vitro assays provided a generally applicable strategy for accelerating the d...

H. S. Mahrosh, M. Christodoulides, A. Jamil · Probiotics and Antimicrobial... · 0 citations