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Open access Aug 2026

Expanding the Biocatalytic Toolbox: A Singular P450 Enzyme Efficiently Produces Diverse Pharmaceutical Metabolites

P450 BM3 is a natural fusion protein with a P450 domain fused to its necessary redox partner and capable of binding a range of fatty acids at high catalytic rates. The flexibility of the active site and catalytic efficiency have led to extensive research aimed at modifying substrate and product profiles for its utiliza...

L. N. Jeffreys, Sian Thistlethwaite, M. Cliff et al. · 0 citations
Open access Jul 2026

Enzymatic glycosylation and amidation reshapes polyene bioactivity

Pathways to previously undescribed polyenes, including unusual enzymes that introduce more sugars onto polyene scaffolds, are discovered, and their accessibility through clean and efficient fermentation and potential for safe use as antifungal treatments is described.

Saadia N. Mirza, Alberto Carella, Joseph W. Thompson et al. · 1 citation

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