BACKGROUND AND OBJECTIVES
To investigate the association between serum levels of glial-related biomarkers, including glycoprotein nonmetastatic melanoma B (GPNMB), soluble triggering receptor expressed on myeloid cells 2 (sTREM2), galectin-3, serpin peptidase inhibitor clade A member 3 (SERPINA3), chitotriosidase-1 (CH...
M. Comabella, Luca Bollo, N. Fissolo et al.· Neurology(R) neuroimmunology...· 0 citations
ABSTRACT Objective To determine the prevalence and clinical characteristics of patients with “low‐positive” (LP) MOG‐IgG (titres 1:160–1:320) among adults with a first demyelinating event (FDE) suggestive of multiple sclerosis (MS). Methods From the Barcelona CIS inception cohort, we included adult patients with serum...
J. Villacieros-Álvarez, Carmen Espejo, G. Arrambide et al.· Annals of Clinical and Trans...· 0 citations
Inhibitory neurons emerged as a key target cell type for MS-associated variants, with seven loci, including STAT3, displaying altered expression only in these cells, suggesting that MS susceptibility may reflect reduced central nervous system resilience to inflammatory challenges.
Lu Zeng, Atlas Khan, Kathryn C. Fitzgerald et al.· Nature Genetics· 0 citations
Failure to reduce zNfL levels after 1 year of treatment was associated with subsequent disease activity, even in patients otherwise considered stable, providing complementary information to clinical and MRI-based monitoring.
Victoria Fernández, A. Pappolla, P. Carbonell-Mirabent et al.· Neurology· 1 citation
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