Reduced NLRP3, AIM2 and NLRC4 inflammasome activity in cord blood of extremely preterm infants
Background Pro-inflammatory caspase-1 is a key player in innate immunity. Physiological activation of the inflammasome/caspase-1 pathway supports host defense against pathogens, whereas dysregulated activation contributes to the pathogenesis of neonatal diseases such as bronchopulmonary dysplasia. Although preterm infan...