Background The genetic architecture of Alzheimer disease remains incompletely understood. Founder populations such as the Amish offer a unique opportunity to identify additional genetic variation influencing the disease. Method Using extensive pedigree and genomic data from Midwestern Amish communities, we estimated bo...
Yi-Ning Liu, Yeunjoo E. Song, Wei-Huan Wang et al.· medRxiv· 0 citations
Epigenetic aging clocks based on DNA methylation patterns across the genome have emerged as a potential biomarker for risk of age-related diseases, like Alzheimer’s disease (AD), and environmental and social stressors. However, methylation clocks have not been comprehensively validated in genetically diverse individual...
Genetically defined ancestry alters NPS prevalence estimates in AD, suggesting that standard race categories obscure population-level disease burden and compromise risk stratification, screening, and trial design.
A. Kumar, B. Kannappan, N. Ray et al.· medRxiv· 0 citations
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