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Open access Aug 2026

A unified framework for local-ancestry-aware genetic association analysis across biobanks

Biobanks increasingly include individuals with admixed genomes, yet conventional genome-wide association study frameworks either exclude participants who cannot be confidently assigned to a discrete ancestry group or ignore ancestry-specific effects. We present FELIX, a scalable framework for local-ancestry-aware genet...

L. Hu, T. Tan, K. Yuan et al. · 0 citations
Open access Aug 2026

Scalable context-dependent single-cell eQTL mapping reveals disease-relevant regulatory variation beyond static models

Many disease-associated variants are thought to act through gene regulation, yet conventional eQTL mapping explains only a fraction of GWAS loci, potentially because regulatory effects vary across cellular states and environments. We present CASTIE, a scalable Poisson mixed-model framework that directly models sparse s...

Yijia Christiana Liu, A. Cuomo, Yi Huang et al. · 0 citations

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