Open access
Sep 2026
Massively parallel characterization reveals context-dependent and non-additive regulatory effects of closely spaced variant pairs
Precise control of gene expression relies in part on cis-regulatory elements (CREs), including enhancers. Genetic variation within enhancers can alter their regulatory activity and contribute to variation in gene expression, yet the effects of multiple nearby variants within the same enhancer remain poorly understood....
Rita Kreevan, V. Pankratov, D. Yermakovich et al.
· bioRxiv · 0 citations