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M. Demaria

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Review Open access Oct 2026

Cellular senescence: six decades of discovery and reinvention.

Cellular senescence has undergone a remarkable conceptual evolution since its discovery in 1961. Initially described by Hayflick and Moorhead as the finite proliferative lifespan of cultured human cells, senescence was first viewed as a consequence of cellular aging. The identification of telomere shortening, senescenc...

Myrthe Klaver, L. S. Steeneken, Naomi Veeningen et al. · 0 citations

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