Author

M. di Antonio

2 papers indexed here

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Open access Oct 2026

PNA-ligand conjugates enable site-selective and directional targeting of adjacent G-quadruplexes

G-quadruplexes (G4s) are non-canonical DNA structures enriched in gene promoters and involved in transcriptional regulation, making them attractive drug targets, albeit difficult to target individually with high specificity due to their structural similarity. In the human c-KIT promoter, three adjacent G4 motifs (c-KIT...

Raffaele Graziano, Enrico Cadoni, Simona Marzano et al. · Chemical Science · 0 citations

Open access Sep 2026

Toxicity of MAPT 4R RNA Contributes to Motor Neuron Degeneration in ALS

MAPT (Tau) dysregulation is implicated in several neurodegenerative diseases, but its contribution to amyotrophic lateral sclerosis (ALS) is poorly understood. Here we show that mRNA isoforms encoding 4-repeat (4R) Tau are upregulated and cytoplasmically enriched in iPSC-derived motor neurons (MNs) from VCP-mutant and...

H. Crerar, Michele Stasi, Koustav Pal et al. · bioRxiv · 0 citations