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Author

M. di Forti

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Review Oct 2026

Cannabis use and subsequent onset of manic symptoms and bipolar disorder: A systematic review and meta-analysis.

BACKGROUND Bipolar disorder is a disabling psychiatric condition affecting approximately 2% of the population, for which identifying modifiable risk factors prior to illness onset is a research priority. Cannabis use is highly prevalent, yet its role in the development of bipolar-spectrum outcomes remains unclear. Prev...

Cecilia Sanjuan-Ortiz, Paula Querol, C. Aymerich et al. · 0 citations
Open access Sep 2026

455. Effects of adolescent cannabinoid exposure on DNA methylation in Erbb4 conditional knockout and wild-type mice

Abstract Background Adolescent cannabis use is associated with an increased risk of psychosis, yet the underlying molecular mechanisms remain poorly understood. Emerging evidence also pointed to genetic liability shaping individual risk of cannabis-induced psychosis. The neuregulin–ErbB4 signalling pathway, implicated...

Z. Li, D. Mukherjee, E. Dempster et al. · 0 citations
Open access Aug 2026

Genetic architecture of treatment-resistant schizophrenia across East Asian and European cohorts: insights from GWAS, TWAS, and synaptic pathway analyses

There is promise in pathway-level and multi-omics approaches to elucidate biologically meaningful heterogeneity within SSD and support for synaptic mechanisms as potential targets for understanding and stratifying treatment-resistance is provided.

P. B. Leung, K. C. Wong, S. Smart et al. · 0 citations
Jul 2026

IQ and subclinical psychosis: The role of psychosocial stressors and core schemata.

BACKGROUND AND HYPOTHESIS Previous research in both clinical and non-clinical populations has suggested an association between intelligence quotient (IQ) and psychosis. The social defeat hypothesis posits that low status and repeated humiliation increase the risk of psychosis. The present study investigated the relatio...

Veronica Sandroni, A. Szöke, H. Peyre et al. · 0 citations
Open access Aug 2026

Integrating biological pathway polygenic scores and trauma in psychosis: findings from the EU-GEI study

Findings provide proof-of-concept for the utility of pPGSs in psychiatric research, suggesting both genetic contributions to trauma exposure and GxE effects on psychosis risk, as well as supporting pathway-specific contributions beyond general polygenic risk.

G. Trotta, I. Austin-Zimmerman, E. Spinazzola et al. · 0 citations

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