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M. Di Nicola

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2 papers indexed here

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Review Open access Sep 2026

686. Glutamate dysfunction in treatment-resistant depression: translational and clinical insights

Abstract Background Treatment-resistant depression (TRD) represents a major clinical challenge and is associated with substantial symptom burden, functional impairment, and poor prognosis. Beyond traditional monoaminergic models, converging evidence indicates that dysfunction of the glutamatergic system plays a central...

M. Di Nicola, M. Pepe, G. Martinotti · 0 citations
Review Open access Aug 2026

Evaluating seltorexant as a treatment option for major depressive disorder.

INTRODUCTION Major depressive disorder is a leading cause of disability, with a significant rate of patients responding inadequately to antidepressants, and residual symptoms, including insomnia, worsening overall outcomes. Current adjunctive options display partial efficacy and tolerability, motivating the search for...

M. Di Nicola, M. Pepe, I. Marcelli et al. · 0 citations

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