Genetic predisposition to IL-1α autoantibodies is associated with reduced risk of rheumatoid arthritis and certain cancers, whereas genetic predisposition to IL-6 autoantibodies is associated with increased risk of diabetes, mirroring prior clinical observations.
J. V. von Stemann, Joseph Dowsett, R. Teglgaard et al.· Nature Communications· 0 citations
The results underscore the role of psychiatric genetic liability, beyond diagnosed psychiatric disorders, in contributing to both COVID-19 and other respiratory infection severity, and provide insights that may improve future risk stratification and public health strategies targeting respiratory viruses.
K. Kõiv, R. Askeland, L. N. Christoffersen et al.· Genome Medicine· 0 citations
BPD showed the strongest positive genetic correlations with GWAS of post-traumatic stress disorder, depression, attention deficit hyperactivity disorder, antisocial behavior, antisocial behavior, and measures of suicide and self-harm.
F. Streit, S. Awasthi, Alisha S. M. Hall et al.· Nature Genetics· 1 citation
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