M. Diken

Chemically synthesized, non-capped and non-polyadenylated peptide-coding RNA efficiently induces antigen-specific CD8+ T cells.

This work shows that short, chemically synthesized RNA oligonucleotides lacking some or all of these features are efficiently translated when they encode epitopes recognized by CD8+ T cells and introduces the possibility that defective or supposedly non-coding RNA may encode human and murine major histocompatibility co...