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M. Dillard

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Open access Jul 2026

Receptor allostery promotes context-specific Sonic Hedgehog signaling during embryonic development

Sonic Hedgehog (SHH) signaling functions in temporal- and context-dependent manners to pattern diverse tissues during embryogenesis. The signal transducer Smoothened (SMO) is induced by sterols, oxysterols, and arachidonic acid (AA) through binding pockets in its extracellular cysteine-rich domain (CRD) and 7-transmemb...

M. Dillard, Christina A. Daly, Rojalin Pradhan et al. · 0 citations

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