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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

M. Dombrovska

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Open access Oct 2026

Polygenic risk for type 2 diabetes modulates gut microbiome associations across metabolic health traits

In this study, we integrated phenotype data, genotyping, and gut metagenomic data to investigate how genetic predisposition to T2D interacts with the gut microbiome, as well as attenuating lifestyle factors, across metabolic health traits in a cohort of 821 individuals of European ancestry. We evaluated increased B...

Lauma Jagare, I. Elbere, M. Rozenberga et al. · 0 citations
Open access Jul 2026

Cross-definition GWAS of IBS in 2.8 million individuals reveals cardiometabolic and triglyceride-linked mechanisms

This study provides the most comprehensive assessment of IBS genetics to date, demonstrating reproducible polygenic inheritance and linking IBS risk to convergent neurogastrointestinal and novel cardiometabolic mechanisms, highlight specific biological pathways and actionable mechanisms and outline translational opport...

Biagio Di Lorenzo, L. Camargo Tavares, Cristian Díaz-Muñoz et al. · 0 citations

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