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Open access Aug 2026

Crosstalk between S-nitrosylation and glycation defines a metabolic vulnerability in liver and renal cancers

It is demonstrated that pharmacological inhibition of the glyoxalase system—the major pathway for MGO detoxification—restores drug sensitivity in patient-derived cells and xenograft models, revealing a context-dependent metabolic vulnerability in AKR1A1 loss conditions.

Chiara Pecorari, Mojca Bratina, Evelyn Gonzalez et al. · 1 citation
Open access Sep 2026

Receptor-defined targeting of a genomically unique melanoma-enriched noncanonical antigen

Effective T cell–based immunotherapies require functional receptors that can be engineered and redeployed to recognize tumor-restricted antigens. Noncanonical peptides arising from transcription outside annotated protein-coding regions expand the antigenic landscape of cancer; however, systematic strategies to biologic...

T. Hulen, M. D. Crowther, Luke Alexander Schuster et al. · 0 citations

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