This work isolated adipocytes from subjects with and without insulin resistance and subjected them to transcriptional and epigenomic profiling, allowing it to identify genes, cis-regulatory elements, and pathways that associate with insulin resistance in this critical cell type.
Qian-Bin Zhang, Audrey Zhou, A. Maynard et al.· Cell Reports· 0 citations
Abstract Obesity, a major risk factor for metabolic disease, has increased in industrialized nations alongside a reduction in gut microbiota diversity. Reconstituting laboratory mice with complex, natural microbiota and commensals from wild mice resulted in protection against diet-induced obesity. These natural microbi...
Shahar Azar, Oksana Gavrilova, Greta Baker et al.· Gut microbes· 0 citations
Background Adipose tissue surrounding the heart and vasculature plays critical roles in cardiovascular homeostasis and disease, yet the cellular and molecular milieu of these depots at single-cell resolution remains incompletely characterized. Understanding how regional adipocytes differ transcriptionally and communica...
Khanh-Van Tran, B. Ofosuhene, Anton Gulko et al.· bioRxiv· 0 citations
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